Reversibility

I think we mostly agree on the relevant facts? i.e. There are too many unknowns to make absolute claims like “physical interactions are fundamentally reversible” without caveats.

That said, if I get your point correctly, you question whether the QM picture is accurate or even testable for macroscopic systems. To comment on that point, I thought e.g. superconductors and Bose-Einstein condensates constitute macroscopic quantum phenomena (to be specific given the context, phenomena that are presently best explained by the SM).

Taking a step back, while some interpretations might differ only in purely philosophical ways, isn’t the open question simply how accurate the wave function picture is? I don’t see questions of “are wave functions real?” or “is collapse real?” as categorically different than “is there a coherent theory of quantum gravity?” as long as the one interprets the questions and answers as empirical.

Exactly. There some macroscopic quantum effects, such as superconductivity, but those are exceptions and in fact large but very simply structured systems. We cannot solve the QM equations for a drop of water, so we cannot test if QM is applicable to a drop of water.

If you ask that question, you already imply that it might not be the Fundamental Truth of the universe. Which I agree with! I’d phrase the question a bit more generally: what are the limits of validity of the wave function picture?

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